• Xin-Liang Yao, Xue-Li Lu, Cheng-Yun Yan, Qi-Lin Wan, Guan-Chang Cheng, and Yan-Ming Li.
• Department of Cardiology, Huaihe Hospital of Henan University Kaifeng 475000, Henan Province, China.
• Int J Clin Exp Patho. 2015 Jan 1; 8 (12): 16014-9.

BackgroundMicroRNAs (miRNAs) play key roles in cardiac development, and the expression of miRNAs is altered in the diseased heart. The aim of this study was to explore the value of circulating microRNA-122-5p (miR-122-5p) as a potential biomarker for acute myocardial infarction (AMI).MethodsPlasma samples from 50 patients with AMI and 39 healthy adults (non-AMI controls) were collected. The abundance of circulating miR-122-5p was measured using quantitative real-time PCR (qRT-PCR). The cTnI concentrations of these samples were analyzed by ELISA.ResultsOur findings revealed that circulating miR-122-5p expression were increased in AMI patients at 4 h, 8 h, 12 h, and 24 h by contrast to those non-AMI controls and displayed similar trends to that of cTnI concentrations in AMI patients. Further study showed that there is a high correlation between circulating miR-122-5p and cTnI concentrations. At last, the receiver operating characteristic (ROC) curve was performed and showed that circulating miR-122-5p had considerable diagnostic accuracy for AMI with an area under curve (AUC) of 0.855.ConclusionsOur results implied that circulating miR-122-5p could be a potential biomarker for AMI.

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