• Konstantinos Agiannitopoulos, Panagiota Pavlopoulou, Konstantinos Tsamis, Konstantina Bampali, Pinelopi Samara, George Nasioulas, George Mertzanos, Dimitrios Babalis, and Klea Lamnissou.
• Division of Genetics & Biotechnology, Department of Biology, National & Kapodistrian University of Athens, Athens, Greece kagiannitopoulos@yahoo.gr.
• In Vivo. 2018 Mar 1; 32 (2): 313-318.

Background/AimCertain microRNAs (miRs) present in human plasma are candidate biomarkers for cardiovascular diseases, including acute myocardial infarction (AMI). We examined the expression of two cardiac-specific miRs (miR-208b and miR-499) in a Greek pathological population.Materials And MethodsPlasma samples from AMI patients and healthy subjects (controls) were analyzed using TaqMan® MicroRNA assays.ResultsThe concentration of both miRs was significantly elevated in AMI patients compared to healthy controls. Moreover, receiver-operating characteristic (ROC) curve analysis showed that miR-208b and miR-499 displayed similar properties with the established AMI biomarker cardiac troponin T (cTnT).ConclusionWe showed, for the first time, that these miRs could be used as AMI biomarkers in our population as well. Our data are in agreement with those of studies based on different population groups and further strengthen the observation that plasma levels of circulating miR-208b and miR-499 could serve as potential AMI biomarkers.Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

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