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Clinical endocrinology · Feb 2008
Clinicopathological correlations of Bcl-xL and Bax expression in differentiated thyroid carcinoma.
- M Asunción Martínez-Brocca, Carolina Castilla, Elena Navarro, M José Amaya, Paulino Travado, Miguel A Japón, and Carmen Sáez.
- Endocrinology Unit, Hospital Universitario Virgen del Rocio, Seville, Spain.
- Clin. Endocrinol. (Oxf). 2008 Feb 1; 68 (2): 190-7.
ObjectiveThe Bcl-2 family proteins are essential mediators in the apoptotic process. Our aim was to investigate whether anti-apoptotic Bcl-xL and pro-apoptotic Bax were over-expressed in a large series of differentiated thyroid carcinomas (DTC) and to study their association with tumour presentation at diagnosis and prognosis.Design And PatientsWe examined the immunohistochemical expression of Bcl-xL and Bax in benign nodular thyroid disease (BNTD) and DTC and their association with clinicopathological parameters. Thyroid tissue samples were collected from an unselected series of patients undergoing surgical resection for DTC (n = 74) or BNTD (n = 15).ResultsAmong DTC cases, expression of Bcl-xL was found to be high in 43.2% and low or absent in 56.8%. Expression of Bax was high in 75.7% and low or absent in 24.3%. Non-neoplastic thyroid tissue was largely unstained for both proteins. Among BNTD cases, expression of Bcl-xL was high in 13.3% and low or absent in 86.6%. Expression of Bax was high in 14.3% and low or absent in 86.6%. A significant association was found between Bcl-xL expression and the presence of high-risk histological subtype (P < 0.05), and regional lymph node (P < 0.01) and distant metastases (P < 0.01). The association between high Bcl-xL expression levels and a longer time of persistent disease after radioiodine ablation was also significant (P < 0.01). Bcl-xL expression was confirmed as an independent prognostic factor for persistent disease in DTC (relative risk, 2.5; 95% confidence interval, 1.1-5.9; P < 0.05).ConclusionsImmunohistochemical expression of Bcl-xL might be a valuable tool in the prediction of tumour aggressiveness in DTC.
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