• Brit J Hosp Med · Nov 2011

    Case Reports

    Pulmonary and paradoxical embolism with platypnoea-orthodeoxia.

    • Santhosh Seetharaman, Boris Lams, Anthony Rudd, and Jonathan Birns.
    • Department of ageing and Health, St. Thomas's Hospital, London.
    • Brit J Hosp Med. 2011 Nov 1; 72 (11): 652-3.

    AbstractThis article outlines the case of a 62-year-old man who presented with a deep vein thrombosis, pulmonary embolus and right middle cerebral artery territory ischaemic stroke in association with a patent foramen ovale with right-to-left shunting. Despite anticoagulation, he was noted to have desaturation and tachypnoea when upright, without other symptoms or cardiovascular compromise, that resolved on lying down. The article describes the syndrome of platypnoea-orthodeoxia, characterized by breathlessness, hypoxia and/or cyanosis while in the upright position that improves on lying down, its relationship to this case, and its resolution by closure of the patent foramen ovale.

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