• Pathologie-biologie · Jun 2014

    [The impact of donor naive and memory T cell subsets on patient outcome following allogeneic stem cell transplantation: relationship between infused donor CD4+/CCR7+ T cell subsets and acute graft-versus-host disease].

    • B Choufi, S Thiant, J Trauet, M Cliquennois, M Cherrel, F Boulanger, V Coiteux, L Magro, M Labalette, and I Yakoub-Agha.
    • EA2686, laboratoire d'immunologie, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France; Service d'hématologie, center hospitalier de Boulogne-sur-mer, BP 609, 62321 Boulogne-sur-mer cedex, France.
    • Pathol. Biol. 2014 Jun 1; 62 (3): 123-8.

    AbstractIn a previous prospective study on 62 patients who underwent an HLA-matched allogeneic stem cell transplantation, we have observed that proportion of donor-derived CCR7(+)/CD4(+) T cells in the graft provided a predictive indicator of acute GVHD without interfering on chronic GVHD and relapse rate. Here we present our results on a confirmatory cohort of 137 consecutive patients. Indeed patients who received more than 76% of CCR7(+)/CD4(+) T cells in the graft developed more often acute GVHD be it of low or high grade than those who did not. Determination of the CCR7(+)/CCR7(neg) ratio of CD4(+) T cells in the graft provides a predictive indicator of acute GVHD and could help to define strategies of partial selective T cell depleted transplantation. Copyright © 2014. Published by Elsevier SAS.

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