• Neurology · Jun 2004

    Comparative Study Clinical Trial

    One week on/one week off: a novel active regimen of temozolomide for recurrent glioblastoma.

    • W Wick, J P Steinbach, W M Küker, J Dichgans, M Bamberg, and M Weller.
    • Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen Medical School, Germany.
    • Neurology. 2004 Jun 8; 62 (11): 2113-5.

    AbstractTwenty-one patients with recurrent or progressive glioblastoma were enrolled in a prospective phase II trial to determine the safety and efficacy of a 1-week on/1-week off regimen of temozolomide administered at 150 mg/m2 on days 1 to 7 and days 15 to 21 of 28-day treatment cycles. Two patients achieved a partial response (10%), and 17 patients (81%) had stable disease. The median progression-free survival was 5 months. The progression-free survival at 6 months was 48%.

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