• Jialiang Chen, Jie Ma, Xinyuan Liu, Shaojie Duan, Ning Liang, and Shukun Yao.
• Graduate School, Beijing University of Chinese Medicine.
• Medicine (Baltimore). 2020 Jan 1; 99 (3): e18703e18703.

BackgroundObesity has become a serious public health issue. The role of Helicobacter pylori (H. pylori) infection in overweight or obesity is inconsistent and controversial. It is very necessary to conduct a systematic review and meta-analysis for determining whether H. pylori infection was associated with risk of overweight/obesity.MethodsFour databases (PubMed, Web of Science, The Cochrane Library, and EMBASE) will be searched from the inception to January 15, 2019. All observational studies (including cross-sectional, case-control or longitudinal studies) reporting the association between H. pylori infection and overweight/obesity will be included. The primary outcome was the presence and incidence of overweight/obesity in conjunction with H. pylori infection. Study selection, data extraction, and assessment of quality will be conducted independently by 2 reviewers. RevMan 5.3 and STATA 14.0 software will be used for data synthesis.ResultsThe results of this study will provide a better understanding of the role of H. pylori infection in overweight/obesity among overall population.ConclusionThis systematic review and meta-analysis will generate evidence of the association between H. pylori infection and overweight/obesity, and the findings of this study will be published in a peer-reviewed journal.PROSPERO registration number: CRD42019121939.

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