• Breast · Aug 2016

    Clinical Trial

    Five-year results of a prospective clinical trial investigating accelerated partial breast irradiation using 3D conformal radiotherapy after lumpectomy for early stage breast cancer.

    • Kathleen C Horst, Carolina Fasola, Debra Ikeda, Bruce Daniel, Grant Ognibene, Don R Goffinet, and Frederick M Dirbas.
    • Department of Radiation Oncology, Stanford University School of Medicine and Stanford Cancer Institute, Stanford, CA 94305, USA. Electronic address: kateh@stanford.edu.
    • Breast. 2016 Aug 1; 28: 178-83.

    BackgroundAccelerated partial breast irradiation (APBI) is emerging as an alternative to whole-breast irradiation. This study presents the results of a prospective trial evaluating 3-dimensional conformal radiotherapy (3D-CRT) to deliver APBI for early-stage breast cancer.MethodsPatients with unifocal stage 0-II breast cancer measuring ≤2.5 cm without lymph node involvement were eligible. After lumpectomy, 3D-CRT APBI was delivered to the lumpectomy cavity + margin (34-38.5 Gy in 10 fractions over 5 days).Results141 patients with 143 breast cancers (2 bilateral) were treated with 3D-CRT APBI. Median age was 60. Median tumor size was 1.1 cm. At a median follow up of 60 months (range, 5-113), the 5-year and 8-year cumulative incidence rate of a true recurrence is 0.9%. The 5-year and 8-year cumulative incidence rates of an elsewhere failure are 2.4% and 4.4%, respectively. The 5-year and 8-year overall survival is 100% and 94%, respectively. Among the 62 patients with follow up >5 years, 95% had excellent/good cosmetic results.ConclusionsOur experience with 3D-CRT APBI demonstrates excellent cosmesis and local control. Longer follow up will be necessary to evaluate long-term efficacy and toxicity of 3D-CRT APBI. CLINICALTRIALS.Gov IdentifierNCT00185744.Copyright © 2016 Elsevier Ltd. All rights reserved.

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