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Multicenter Study Comparative Study
Multi-center validation of the transferability of the magnetic resonance T2* technique for the quantification of tissue iron.
- Mark A Tanner, Taigang He, Mark A Westwood, David N Firmin, Dudley J Pennell, and Thalassemia International Federation Heart T2* Investigators.
- Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, UK.
- Haematologica. 2006 Oct 1; 91 (10): 1388-91.
AbstractThe transferability of the T2* technique for measurement of tissue iron between magnetic resonance (MR) scanners is unknown. Heart and liver multi-breath-hold T2* sequences were installed on MR scanners at six different sites. T2* was assessed locally in five or more patients with thalassemia major (n=39), and subjects were re-scanned at the standardization center in London. Inter-center reproducibility of T2* in heart and liver was 5.0% and 7.1%, with mean absolute differences in T2* of 1.3 ms and 0.45 ms, respectively. The MR multi-breath-hold T2* technique for tissue iron quantification is transferable between scanners with good reproducibility.
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