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- Massimo Libra, Roberto Sorio, Angela Buonadonna, Massimiliano Berretta, Peter Stefanovski, Giuseppe Toffoli, Giovanna Mazzaglia, Nicoletta Cordani, Franca Stivala, and Mauro Boiocchi.
- Division of Medical Ontology, Centro di Riferimento Oncologico, Aviano, Italy.
- Tumori. 2003 May 1; 89 (3): 311-3.
AbstractPlatinum-based therapy is considered the standard treatment for patients with advanced ovarian cancer. Carboplatin has a more favorable toxicity profile than cisplatin; however, hypersensitivity reactions to carboplatin have been reported occasionally. We reviewed 112 cases of ovarian cancer treated with carboplatin at our institute to identify the hypersensitivity reactions to this chemotherapeutic agent. Hypersensitivity reactions were documented in nine cases (8%). No deaths occurred, but the reactions were judged severe in three of the 112 patients (2.6%). In our own experience with patients showing idiosyncrasy to carboplatin we observed successful resolution after retreatment with cisplatin. Since patients who relapse after initial treatment with carboplatin often respond to it a second time, it is important to continue this treatment.
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