• Hai Guo, Hong Zheng, Jian-rong Ye, and Hui-cai Wang.
• Department of Anesthesiology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
• Zhonghua Wei Chang Wai Ke Za Zhi. 2011 Jul 1;14(7):524-8.

ObjectiveTo assess whether goal-directed fluid management can prevent gastrointestinal complications in major surgery.MethodsElectronic databases including Cochrane library(Issue 3,2010), Pubmed, EMbase, Highwire, CBM, and CNKI were searched. The date of search was between January 2000 and December 2010. Randomized controlled trials(RCTs) were indentified studying association of goal-directed therapy (GDT) with gastrointestinal complications. Study selection and meta-analysis were conducted according to the Cochrane Handbook for systematic reviews. Data were extracted from these trials by 3 reviewers independently and analyzed by RevMan 5.0 software.ResultsTen trials involving 775 patients were included. GDT significantly improved oxygen supply(WMD=82.95, 95% CI: 17.43-148.46). GDT reduced postoperative hospital stay(WMD=-2.06, 95% CI: -2.95 - -1.17) and decreased postoperative complication rate after major surgery(RR=0.39, 95% CI: 0.29-0.52).ConclusionGoal-directed fluid management can stabilize cardiac output, augment oxygen supply, and therefore reduce postoperative complications.

11 keywords...

hide…