• Int. J. Neurosci. · Mar 2018

    Review

    Large animal models of traumatic brain injury.

    • Jun-Xi Dai, Yan-Bin Ma, Nan-Yang Le, Jun Cao, and Yang Wang.
    • a Department of Neurosurgery, Shanghai Ninth People's Hospital , Shanghai Jiao Tong University School of Medicine , Shanghai , China.
    • Int. J. Neurosci. 2018 Mar 1; 128 (3): 243-254.

    AbstractPurpose/Aim: Animal models of traumatic brain injury (TBI) provide powerful tools to study TBI in a controlled, rigorous and cost-efficient manner. The mostly used animals in TBI studies so far are rodents. However, compared with rodents, large animals (e.g. swine, rabbit, sheep, ferret, etc.) show great advantages in modeling TBI due to the similarity of their brains to human brain. The aim of our review was to summarize the development and progress of common large animal TBI models in past 30 years.

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