• Gan To Kagaku Ryoho · Mar 2002

    Review

    [Rituximab, a chimeric anti-CD20 monoclonal antibody, in the treatment of B-cell lymphoma].

    • Kensei Tobinai.
    • Hematology Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
    • Gan To Kagaku Ryoho. 2002 Mar 1; 29 (3): 473-80.

    AbstractIn September 2001, rituximab, a chimeric mouse-human anti-CD20 monoclonal antibody, was approved for the treatment of B-cell lymphoma by the Japanese government. Rituximab is the first monoclonal antibody that was approved for the treatment of malignant neoplasms by the U.S. Food and Drug Administration (FDA). Several clinical trials of rituximab conducted in USA, Europe and Japan revealed its promising therapeutic efficacy for B-cell lymphoma. Its minimal myelotoxicity allows rituximab to be combined with full doses of anticancer agents. Ongoing clinical trials will define the future role of rituximab in the treatment of B-cell lymphoma.

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