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- Megan E Poorman, Ieva Braškutė, Lambertus W Bartels, and William A Grissom.
- Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee.
- Magn Reson Med. 2019 Apr 1; 81 (4): 2385-2398.
PurposeTo perform multi-echo water/fat separated proton resonance frequency (PRF)-shift temperature mapping.MethodsState-of-the-art, iterative multi-echo water/fat separation algorithms produce high-quality water and fat images in the absence of heating but are not suitable for real-time imaging due to their long compute times and potential errors in heated regions. Existing fat-referenced PRF-shift temperature reconstruction methods partially address these limitations but do not address motion or large time-varying and spatially inhomogeneous B0 shifts. We describe a model-based temperature reconstruction method that overcomes these limitations by fitting a library of separated water and fat images measured before heating directly to multi-echo data measured during heating, while accounting for the PRF shift with temperature.ResultsSimulations in a mixed water/fat phantom with focal heating showed that the proposed algorithm reconstructed more accurate temperature maps in mixed tissues compared to a fat-referenced thermometry method. In a porcine phantom experiment with focused ultrasound heating at 1.5 Tesla, temperature maps were accurate to within 1∘ C of fiber optic probe temperature measurements and were calculated in 0.47 s per time point. Free-breathing breast and liver imaging experiments demonstrated motion and off-resonance compensation. The algorithm can also accurately reconstruct water/fat separated temperature maps from a single echo during heating.ConclusionsThe proposed model-based water/fat separated algorithm produces accurate PRF-shift temperature maps in mixed water and fat tissues in the presence of spatiotemporally varying off-resonance and motion.© 2018 International Society for Magnetic Resonance in Medicine.
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