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Microbes and infection · Jun 2013
Dectin-1 plays a redundant role in the immunomodulatory activities of β-glucan-rich ligands in vivo.
- Mohlopheni J Marakalala, David L Williams, Jennifer C Hoving, Rolf Engstad, Mihai G Netea, and Gordon D Brown.
- Division of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa.
- Microbes Infect. 2013 Jun 1; 15 (6-7): 511-5.
Abstractβ-Glucans are known for their ability to trigger both protective and damaging immune responses. Here we have explored the role of the beta-glucan receptor Dectin-1 in archetypical models of protective and non-protective immunomodulation induced by beta-glucan rich ligands. In the first model, we explored the role of Dectin-1 in the ability of soluble purified β-glucans to mediate protection against systemic Staphylococcus aureus infection in mice. In the second model, we explored the role of Dectin-1 in zymosan induced multiple organ dysfunction syndrome. In both cases, these β-glucan rich compounds had marked effects in vivo which were unaltered by Dectin-1 deficiency, suggesting that this receptor has a redundant role in these murine models.Copyright © 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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