• Mannudeep K Kalra, Fatemeh Homayounieh, Chiara Arru, Ola Holmberg, and Jenia Vassileva.
• Department of Radiology, Webster Center for Quality and Safety, Massachusetts General Hospital, 75 Blossom Court, Suite 236, Room 248, Boston, MA, 02114, USA.
• Eur Radiol. 2020 Dec 1; 30 (12): 6554-6560.

AbstractThe global pandemic of coronavirus disease 2019 (COVID-19) has upended the world with over 6.6 million infections and over 391,000 deaths worldwide. Reverse-transcription polymerase chain reaction (RT-PCR) assay is the preferred method of diagnosis of COVID-19 infection. Yet, chest CT is often used in patients with known or suspected COVID-19 due to regional preferences, lack of availability of PCR assays, and false-negative PCR assays, as well as for monitoring of disease progression, complications, and treatment response. The International Atomic Energy Agency (IAEA) organized a webinar to discuss CT practice and protocol optimization from a radiation protection perspective on April 9, 2020, and surveyed participants from five continents. We review important aspects of CT in COVID-19 infection from the justification of its use to specific scan protocols for optimizing radiation dose and diagnostic information.Key Points• Chest CT provides useful information in patients with moderate to severe COVID-19 pneumonia.• When indicated, chest CT in most patients with COVID-19 pneumonia must be performed with non-contrast, low-dose protocol.• Although chest CT has high sensitivity for diagnosis of COVID-19 pneumonia, CT findings are non-specific and overlap with other viral infections including influenza and H1N1.

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