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Fetal. Diagn. Ther. · Jan 2007
Multicenter StudyNonimmune hydrops fetalis diagnosed during the second half of pregnancy in Southern China.
- Can Liao, Jiaxue Wei, Qiuming Li, Jian Li, Lixian Li, and Dongzhi Li.
- Prenatal Diagnostic Center, Guangzhou Maternal and Neonatal Hospital, Guangzhou Medical College, Guangzhou, Guangdong, PR China.
- Fetal. Diagn. Ther. 2007 Jan 1; 22 (4): 302-5.
ObjectiveTo analyze the etiologies of nonimmune hydrops fetalis (NIHF) for a southern section of China.Methods138 cases of NIHF presenting after 20 weeks' gestation over a 10-year period were reviewed.ResultsThe causes of fetal hydrops were identified in 92.0%. Homozygous alpha-thalassemia dominated as the cause of NIHF (55.1%), followed by infection (15.2%) and structural abnormalities (10.9%). No obvious cause was identified in 11 cases (8.0%). Termination of pregnancy was performed in 131 cases.ConclusionsHomozygous alpha-thalassemia is the most common cause of NIHF in southern China. An effective prenatal thalassemia screening program should be established in this high prevalence region.Copyright (c) 2007 S. Karger AG, Basel.
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