• R Cárdenas-Cardós, R Rivera-Luna, N A López-Facundo, C Leal-Leal, R Gómez-Martínez, and A Castellanos-Toledo.
• Department of Pediatric Oncology, Instituto Nacional de Pediatría, Mexico City, Mexico.
• Pediatr Hematol Oncol. 1999 Nov 1; 16 (6): 519-23.

AbstractA retrospective analysis of 55 patients with Ewing's sarcoma from an institution in Mexico was done between 1980 and 1993. The ages ranged between 2 and 16 years (mean 9.78); 39 were male and 16 female. The most frequent primary sites were in the humerus in 13 of 55 patients (23.6%), followed by the pelvis in 10 out of 55 (18%). Sixty percent of the patients had metastasic disease at diagnosis; the lungs and bones were the most frequently affected sites. Patients with localized disease (n = 22) had a disease-free survival (DFS) of 44%, compared with 20% of those with pulmonary metastasic disease (n = 7) and 8% of patients with metastasic disease to the lungs and elsewhere (n = 26) (p = .00061). Patients in regimen 3 had a DFS of 47% at 36 months of follow-up compared to 20 and 25% for patients in regimens 1 and 2, respectively (p = .01). In those with trunk presentation the DFS was of 25% and in those with presentation in the extremities DFS was 50% (p = .01). Patients with pulmonary metastasic disease at diagnosis have a DFS of 20% in comparison to those without (44%) (p = .00061).

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