• Ryota Kuroiwa, Yoshihisa Tateishi, Taku Oshima, Takeshi Inagaki, Seiichiro Furukawa, Ryo Takemura, Yohei Kawasaki, and Astushi Murata.
• Division of Rehabilitation Medicine, Chiba University Hospital, Chiba, Japan.
• Indian J Crit Care Med. 2021 Jan 1; 25 (1): 62-66.

AimVentilator-associated pneumonia (VAP) is the most common intensive care unit (ICU)-acquired infection. The current study aimed to assess the efficacy of mechanical insufflation-exsufflation (MI-E) in preventing VAP in critically ill patients.Materials And MethodsThis retrospective cohort study was conducted at the ICU of Chiba University Hospital between January 2014 and September 2017. The inclusion criteria were patients who required invasive mechanical ventilation ≥48 hours and those who underwent rehabilitation, including chest physical therapy (CPT). In 2015, the study institution started the use of MI-E in patients with impaired cough reflex. From January to December 2014, patients undergoing CPT were classified under the historical control group, and those who received treatment using MI-E from January 2015 to September 2017 were included in the intervention group. The patients received treatment using MI-E via the endotracheal or tracheostomy tube, with insufflation-exsufflation pressure of 15-40 cm H2O. The treatment frequency was one to three sessions daily, and a physical therapist who is experienced in using MI-E facilitated the treatment.ResultsFrom January 2015 to September 2017, 11 patients received treatment using MI-E. Of the 169 patients screened in 2014, 19 underwent CPT. The incidence of VAP was significantly different between the CPT and MI-E groups (84.2% [16/19] vs 26.4% [3/11], p = 0.011). After adjusting for covariates, a multivariate logistic regression analysis was performed, and results showed that the covariates were not associated with the incidence of VAP.ConclusionThis retrospective cohort study suggests that the use of MI-E in critically ill patients is independently associated with a reduced incidence of VAP.Clinical SignificanceAssessing the efficacy of MI-E to prevent VAP.How To Cite This ArticleKuroiwa R, Tateishi Y, Oshima T, Inagaki T, Furukawa S, Takemura R, et al. Mechanical Insufflation-exsufflation for the Prevention of Ventilator-associated Pneumonia in Intensive Care Units: A Retrospective Cohort Study. Indian J Crit Care Med 2021;25(1):62-66.Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.

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