• Seminars in oncology · Oct 1996

    Randomized Controlled Trial Comparative Study Clinical Trial

    An ongoing European organization for research and treatment of cancer crossover trial comparing single-agent paclitaxel and doxorubicin as first- and second-line treatment of advanced breast cancer.

    • M J Piccart-Gebhart, P Bruning, T Gamucci, J Klijn, J A Roy, A Awada, Z Kusenda, A Van Vreckem, and R Paridaens.
    • Jules Bordet Institute, Brussels, Belgium.
    • Semin. Oncol. 1996 Oct 1; 23 (5 Suppl 11): 11-5.

    AbstractThe activity of paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) in advanced breast cancer patients who have failed doxorubicin treatment is well established, but the optimal sequence between these two important agents remains to be determined. The European Organization for Research and Treatment of Cancer therefore designed a prospective randomized clinical trial in which patients not exposed to anthracyclines in the adjuvant setting received either first-line paclitaxel, given as a 3-hour infusion at a dose of 200 mg/m2 followed at the time of disease progression by second-line doxorubicin, given as a bolus injection at a dose of 75 mg/m2 or the reverse sequence. The target accrual is 330 patients. Interim results on 207 evaluable patients of 289 randomized are presented.

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