• Amarnath Jena, Shashi Bhushan Mehta, and Sangeeta Taneja.
• MRI Department, Rajiv Gandhi Cancer Institute and Research Center, Rohini, New Delhi, India.
• J Magn Reson Imaging. 2013 Sep 1; 38 (3): 573-9.

PurposeTo assess the effects of reduced scan time in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of breast for the evaluation of pharmacokinetic parameters (K(trans) , ve , and kep ).Materials And MethodsHigh temporal resolution DCE-MRI was performed for calculation of pharmacokinetic parameters (K(trans) , ve , and kep ) at different timepoints using an in-house developed computation scheme adopting the standard model (SM).ResultsThe receiver operating characteristic (ROC) curve analysis revealed an area under the ROC curve (AUC) of 0.994 for K(trans) at 90 seconds and 0.987 for K(trans) at 60 seconds with a significant decrease in the AUC for K(trans) at 30 seconds (0.669). While ve showed a consistently higher AUC (>0.9) at timepoints ≥40 seconds, the AUC for kep showed a consistent decline with reduced acquisition times.ConclusionReducing the acquisition time for the K(trans) and ve measurement up to 60 seconds yields reasonable accuracy for both and can be incorporated in the routine DCE-MRI protocol for evaluation of enhancing breast lesions.Copyright © 2013 Wiley Periodicals, Inc., a Wiley company.

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