• Parkinsonism Relat. Disord. · Aug 2008

    Deep brain stimulation of CM/PF of thalamus could be the new elective target for tremor in advanced Parkinson's Disease?

    • A Peppe, A Gasbarra, A Stefani, C Chiavalon, M Pierantozzi, E Fermi, P Stanzione, C Caltagirone, and P Mazzone.
    • IRCCS Fondazione Santa Lucia, Roma, Italy. a.peppe@hsantalucia.it
    • Parkinsonism Relat. Disord. 2008 Aug 1;14(6):501-4.

    AbstractAim of this study was to investigate whether Deep Brain Stimulation (DBS) of the Centre Median Nucleus/Parafascicular (CM/PF) Complex is useful in reducing extrapyramidal symptoms in advanced Parkinson's Disease (PD) patients. In particular, we compared the action of CM/PF and subthalamic nucleus (STN) DBS on resting hand tremor using EMG surface of ulnar and radial right-hand muscles. Our results show that C/M DBS is very effective in reducing tremor, indicating this complex as a new target in advanced PD patients.

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