• J Clin Neurosci · Jun 2009

    Case Reports

    Long-term use of temozolomide: could you use temozolomide safely for life in gliomas?

    • Mustafa Khasraw, David Bell, and Helen Wheeler.
    • Department of Medical Oncology, Royal North Shore Hospital, Pacific Highway, St Leonards, New South Wales 2065, Australia. mkhasraw@med.usyd.edu.au
    • J Clin Neurosci. 2009 Jun 1; 16 (6): 854-5.

    AbstractTemozolomide (TMZ) is an alkylating agent used in the management of gliomas. Although TMZ is generally safe and acute toxicity is well documented, there are limited data on long-term toxicities. We present three patients with glioma; all patients started on TMZ after having progressed following primary treatment. These patients have continued TMZ for 5 years, 7 years and 8 years respectively. So far they have had no serious side effects. We discuss these patients while raising the question of prolonged TMZ use.

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