• Cancer investigation · Jan 2015

    Quality and Outcomes of Treatment of Hypercalcemia of Malignancy.

    • Jason D Wright, Ana I Tergas, Cande V Ananth, William M Burke, June Y Hou, Ling Chen, Alfred I Neugut, Catherine A Richards, and Dawn L Hershman.
    • a Department of Obstetrics and Gynecology , Columbia University , New York , USA.
    • Cancer Invest. 2015 Jan 1; 33 (8): 331-9.

    AbstractUsing a nationwide database, 4,874 patients with hypercalcemia of malignancy were identified. The in-hospital mortality rate was 6.8%. Overall, 1,971 (40.4%) patients received pamidronate and 1,399 (28.7%) received zoledronic acid during hospitalization. Calcitonin was utilized in 1,337 (27.4%) patients while glucocorticoids were administered to 1,311 (26.9%). Use of contraindicated medications was noted in 136 (2.8%) patients who received thiazide diuretics and 12 (0.2%) who received lithium. Tumor site, presence of bone metastases, and severity of illness were predictors of treatment. There was no association between treatment with bisphosphonates, calcitonin, or glucocorticoids and morbidity or mortality.

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