• Haseem Ashraf, Zaigham Saghir, Asger Dirksen, Jesper Holst Pedersen, Laura Hohwü Thomsen, Martin Døssing, and Philip Tønnesen.
• Department of Respiratory Medicine, Gentofte University Hospital, Hellerup, Denmark Department of Radiology, Akershus University Hospital, Lørenskog, Norway.
• Thorax. 2014 Jun 1; 69 (6): 574-9.

BackgroundWe present the final results of the effect of lung cancer screening with low-dose CT on the smoking habits of participants in a 5-year screening trial.MethodsThe Danish Lung Cancer Screening Trial (DLCST) was a 5-year screening trial that enrolled 4104 subjects; 2052 were randomised to annual low-dose CT (CT group) and 2052 received no intervention (control group). Participants were current and ex-smokers (≥4 weeks abstinence from smoking) with a tobacco consumption of ≥20 pack years. Smoking habits were determined annually. Missing values for smoking status at the final screening round were handled using two different models.ResultsThere were no statistically significant differences in annual smoking status between the CT group and control group. Overall the ex-smoker rates (CT + control group) significantly increased from 24% (baseline) to 37% at year 5 of screening (p<0.001). The annual point prevalence quit rate increased from 11% to 24% during the five screening rounds; the ex-smokers' relapse rate remained stable, around 11%, across the same period.ConclusionsScreening with low-dose CT had no extra effect on smoking status compared with the control group, but overall the screening programme probably promoted smoking cessation.Clinical Trial RegistrationThe DLCST is registered in Clinical Trials.gov Protocol Registration System (identification no. NCT00496977).Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

27 keywords...

hide…