• David L Andolino, Ted Hoene, Lu Xiao, Jeffrey Buchsbaum, and Andrew L Chang.
• Department of Radiation Oncology, Indiana University School of Medicine, Bloomington, IN 46202, USA. dandolin@iupui.edu
• Int. J. Radiat. Oncol. Biol. Phys. 2011 Nov 15; 81 (4): e667-71.

PurposeTo assess the potential reduction in breast dose for young girls with Hodgkin's lymphoma (HL) treated with breast-sparing proton therapy (BS-PT) as compared with three-dimensional conformal involved-field photon radiotherapy (3D-CRT).Methods And MaterialsThe Clarian Health Cancer Registry was queried for female pediatric patients with the diagnosis of HL who received radiotherapy at the Indiana University Simon Cancer Center during 2006-2009. The original CT simulation images were obtained, and 3D-CRT and BS-PT plans delivering 21 Gy or cobalt gray equivalent (CGE) in 14 fractions were created for each patient. Dose-volume histogram data were collected for both 3D-CRT and BS-PT plans and compared by paired t test for correlated samples.ResultsThe cancer registry provided 10 female patients with Ann Arbor Stage II HL, aged 10-18 years at the time of treatment. Both mean and maximum breast dose were significantly less with BS-PT compared with 3D-CRT: 0.95 CGE vs. 4.70 Gy (p < 0.001) and 21.07 CGE vs. 23.11 Gy (p < 0.001), respectively. The volume of breast receiving 1.0 Gy/CGE and 5.0 Gy/CGE was also significantly less with BS-PT, 194 cm(3) and 93 cm(3), respectively, compared with 790 cm(3) and 360 cm(3) with 3D-CRT (p = 0.009, 0.013).ConclusionBreast-sparing proton therapy has the potential to reduce unnecessary breast dose in young girls with HL by as much as 80% relative to involved-field 3D-CRT.Copyright © 2011 Elsevier Inc. All rights reserved.

30 keywords...

hide…