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- Caroline L Holloway, Valerie Panet-Raymond, and Ivo Olivotto.
- BC Cancer Agency--Vancouver Island Centre and University of British Columbia, 2410 Lee Avenue, Victoria, BC, Canada.
- Breast. 2010 Jun 1; 19 (3): 163-7.
AbstractHypofractionated whole breast radiation therapy following breast conserving surgery (BCS) has been used in many institutions for several decades. Four randomized trials with 5-10-year follow-up, have demonstrated equivalent local control, cosmetic and normal tissue outcomes between 50 Gy in 25 fractions and various hypofractionated RT prescriptions employing 13-16 fractions. Indirect evidence suggests that hypofractionated RT may also be safe and effective for regional nodal RT. In the face of equivalent outcomes, patient convenience and health care utilization benefits, hypofractionated RT should be the new 'standard' following BCS.Copyright (c) 2010 Elsevier Ltd. All rights reserved.
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