• Andrew R Segerdahl, Jingyi Xie, Kathryn Paterson, Juan D Ramirez, Irene Tracey, and BennettDavid L HDLH.
• Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), University of Oxford, Oxford, Oxfordshire, UK Wolfson Centre for Age-Related Disease, Kings College London, Hodgkin Building, Guys Campus, SE1 1UL London, UK.
• Pain. 2012 May 1; 153 (5): 112211271122-1127.

AbstractWe identified a patient with severe inherited erythromelalgia secondary to an L858F mutation in the voltage-gated sodium channel Na(v)1.7. The patient reported severe ongoing foot pain, which was exquisitely sensitive to limb cooling. We confirmed this heat hypersensitivity using quantitative sensory testing. Additionally, we employed a novel perfusion imaging technique in a simple block design to assess her baseline erythromelalgia pain vs cooling relief. Robust activations of key pain, pain-affect, and reward-related centres were observed. This combined approach allowed us to confirm the presence of a temperature-sensitive channelopathy of peripheral neurons and to investigate the neural correlates of tonic neuropathic pain and relief in a single subject.Copyright © 2012 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

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