• Florence C F Chang, David S Tsui, Neil Mahant, Nigel Wolfe, Samuel D Kim, Ainhi D Ha, Melissa Drury, Jane M Griffith, and Victor S C Fung.
• Movement Disorders Unit, Department of Neurology, Westmead Hospital, Sydney, Australia.
• Parkinsonism Relat. Disord. 2015 Mar 1; 21 (3): 317-20.

ObjectiveWe report a prospective, open label study of 24 h levodopa-carbidopa intestinal gel (LCIG) as treatment for levodopa "unresponsive" freezing of gait (FOG) associated with Parkinson's disease.Method5 patients with disabling FOG, documented as being levodopa "unresponsive", were commenced on continuous 24 h infusion LCIG therapy with the night-time rate at 50-80% of the daytime infusion rate. Patients underwent baseline, 3 and 6 month gait assessments, documentation of their falls frequency and completed FOG questionnaires.ResultMedian 360° turn time improved by 54%, fall frequency score reduced from 3 to 0 at 6 months, FOG questionnaire score improved by 14% and Timed Up- and -Go 8 m walk was unchanged.Conclusion24 h LCIG therapy may reduce levodopa "unresponsive" FOG and associated falls. A larger prospective study is needed for confirmation.Copyright © 2014 Elsevier Ltd. All rights reserved.

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