• Frontiers in immunology · Jan 2020

    Case Reports

    Case Report: Systemic Inflammatory Response and Fast Recovery in a Pediatric Patient With COVID-19.

    • Adam Klocperk, Zuzana Parackova, Jitka Dissou, Hana Malcova, Petr Pavlicek, Tomas Vymazal, Pavla Dolezalova, and Anna Sediva.
    • Department of Immunology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, Prague, Czechia.
    • Front Immunol. 2020 Jan 1; 11: 1665.

    AbstractWe report a case of an 8-year-old girl who underwent a SARS-CoV-2 infection manifesting with atypical symptoms spearheaded by abdominal discomfort and systemic inflammation and partially mimicking hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS), which however did not fulfill the HLH/MAS diagnostic criteria. In this case of what has since been described as Pediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-COV-2 (PIMS-TS) we documented excellent clinical response to immunosuppression with systemic corticosteroids and intravenous immunoglobulins. We show a detailed longitudinal development of neutrophil immunophenotype which suggests activation and engagement of neutrophils during PIMS-TS with compensatory contraction of the response and contra-regulation of neutrophil phenotype during recovery.Copyright © 2020 Klocperk, Parackova, Dissou, Malcova, Pavlicek, Vymazal, Dolezalova and Sediva.

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