• Int. J. Radiat. Oncol. Biol. Phys. · Oct 2009

    Review

    Biologically effective dose-response relationship for breast cancer treated by conservative surgery and postoperative radiotherapy.

    • George A Plataniotis and Roger G Dale.
    • Department of Oncology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom. george.plataniotis@nhs.net
    • Int. J. Radiat. Oncol. Biol. Phys. 2009 Oct 1; 75 (2): 512-7.

    PurposeTo find a biologically effective dose (BED) response for adjuvant breast radiotherapy (RT) for initial-stage breast cancer.Methods And MaterialsResults of randomized trials of RT vs. non-RT were reviewed and the tumor control probability (TCP) after RT was calculated for each of them. Using the linear-quadratic formula and Poisson statistics of cell-kill, the average initial number of clonogens per tumor before RT and the average tumor cell radiosensitivity (alpha-value) were calculated. An alpha/beta ratio of 4 Gy was assumed for these calculations.ResultsA linear regression equation linking BED to TCP was derived: -ln[-ln(TCP)] = -ln(No) + alpha(*) BED = -4.08 + 0.07 (*) BED, suggesting a rather low radiosensitivity of breast cancer cells (alpha = 0.07 Gy(-1)), which probably reflects population heterogeneity. From the linear relationship a sigmoid BED-response curve was constructed.ConclusionFor BED values higher than about 90 Gy(4) the radiation-induced TCP is essentially maximizing at 90-100%. The relationship presented here could be an approximate guide in the design and reporting of clinical trials of adjuvant breast RT.

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