• Zhong Zheng Jia, Hong Mei Gu, Xue Jun Zhou, Jin Long Shi, Min Da Li, Guo Feng Zhou, and Xian Hua Wu.
• Department of Radiology, Affiliated Hospital of Nantong University, 20 Xisi Road Nantong, 226001 Jiangsu, PR China. Electronic address: jzz2397@163.com.
• Eur J Radiol. 2015 Sep 1; 84 (9): 1805-9.

PurposeThis study was designed to quantitatively evaluate the immature microvascular density (MVD) of brain gliomas using the volume transfer constant (K(trans)) and volume of extravascular extracellular space per unit volume of tissue (Ve) from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) noninvasively.Materials And MethodsFifty-seven patients (35 males, 22 females; age range, 14-70, mean age 46±12 years old) with brain glioma were included in this study. The maximal values of K(trans) and Ve of all patients with brain glioma (grade II 24, III 7 and IV 26) were obtained. The CD105-microvascular density (CD105-MVD) of each tumor was measured in surgical specimen. The differences of K(trans), Ve and CD105-MVD between the different grades of gliomas were analyzed using the Mann-Whitney U-test. The Pearman correlation coefficient was determined between K(trans), Ve and CD105-MVD. A P-value of less than 0.05 was considered statistically significant.ResultsThe differences in K(trans), Ve and CD105-MVD were statistically significant between low-grade glioma (LGG) and high-grade glioma (HGG) (P=0.001, P<0.001, P<0.001). The K(trans), Ve and CD105-MVD of grade II were significantly lower than those of grade III and IV. K(trans) and Ve were positively correlated with CD105-MVD in HGG (P<0.001, P<0.001).ConclusionsOur results suggest DCE-MRI plays an important part in noninvasively evaluating the immature MVD of brain gliomas.Copyright © 2015. Published by Elsevier Ireland Ltd.

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