• Nucl Med Commun · Feb 2007

    Healthy passive cigarette smokers have increased pulmonary alveolar permeability.

    • Clare Beadsmoore, Heok K Cheow, Katherine Szczepura, Prina Ruparelia, and A Michael Peters.
    • Department of Nuclear Medicine, Addenbrooke's Hospital, Cambridge, UK.
    • Nucl Med Commun. 2007 Feb 1; 28 (2): 75-7.

    QuestionDoes passive smoking have a measurable effect on lung function in otherwise healthy subjects? There is current interest concerning passive smoking but no objective evidence showing that it has any impact on lung function.MethodsThe pulmonary clearance rate of (99m)Tc-DTPA was measured in 21 healthy volunteers after inhalation as a radio-aerosol and compared between healthy cigarette smokers, passive smokers and non-smokers. All volunteers had normal lung function.ResultsClearance half-times in healthy passive smokers (n=5) were longer than in healthy smokers (n=6) but clearly shorter compared with healthy non-smokers (n=10) with respective mean values of 45.2 (SD 8.3), 24.3 (8.6) and 80.3 (20) min.ConclusionPassive smoking has a functional impact on the lung blood/gas barrier.

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