• J. Mol. Cell. Cardiol. · Apr 2021

    Pathophysiology and pharmacological management of pulmonary and cardiovascular features of COVID-19.

    • Walid Hamouche, Malik Bisserier, Agnieszka Brojakowska, Abrisham Eskandari, Kenneth Fish, David A Goukassian, and Lahouaria Hadri.
    • Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Internal Medicine Department, Brookdale University Hospital Medical Center, Brooklyn, NY, USA.
    • J. Mol. Cell. Cardiol. 2021 Apr 1; 153: 72-85.

    AbstractThe first confirmed case of novel Coronavirus Disease 2019 (COVID-19) in the United States was reported on January 20, 2020. As of November 24, 2020, close to 12.2 million cases of COVID-19 was confirmed in the US, with over 255,958 deaths. The rapid transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), its unusual and divergent presentation has strengthened the status of COVID-19 as a major public health threat. In this review, we aim to 1- discuss the epidemiological data from various COVID-19 patient cohorts around the world and the USA as well the associated risk factors; 2- summarize the pathophysiology of SARS-CoV-2 infection and the underlying molecular mechanisms for the respiratory and cardiovascular manifestations; 3- highlight the potential treatments and vaccines as well as current clinical trials for COVID-19.Copyright © 2020. Published by Elsevier Ltd.

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