• Osmel La-Llave-León, Rodrigo Lugo-Soto, Marisela Aguilar-Durán, Sergio Estrada-Martínez, José-Manuel Salas-Pacheco, Ada Sandoval-Carrillo, Francisco Xavier Castellanos-Juárez, Marcel Barraza-Salas, Fernando Vázquez-Alanís, and Gonzalo García-Vargas.
• a Instituto de Investigación Científica , Universidad Juárez del Estado de Durango , Durango, Durango , México.
• Women Health. 2015 Jan 1; 55 (1): 90-102.

AbstractSeveral studies have revealed a negative association between blood lead levels and hematological impairment. In this cross-sectional study, we examined the relationship between blood lead levels and hematological indices in 292 pregnant women from Durango, Mexico. Apparently healthy pregnant women, aged 14-41 years and at 3-41 weeks of gestation, were recruited between June 2007 and May 2008. Blood lead and hematological indices were measured. The mean blood lead was 2.79 ± 2.16 μg/dL, and lead levels ≥ 5 μg/dL were detected in 25 women (8.6%). Hemoglobin, hematocrit, and red blood cells count were significantly higher in pregnant women with a blood lead concentration of ≥ 5 μg/dL than the group with lower blood lead levels (p < .05). Mean corpuscular volume and mean corpuscular hemoglobin were not significantly related to lead levels. Hemoglobin and hematocrit showed a non-significant positive correlation with blood lead, but the correlation between red blood cell count and blood lead levels was statistically significant (r = 0.185, p = .002). The findings suggest that a positive association between blood lead and some hematological indices may occur at relatively low blood lead concentration (mean < 5 μg/dL).

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