• Int. J. Radiat. Oncol. Biol. Phys. · Nov 2005

    Quality control of involved-field radiotherapy in patients with advanced Hodgkin's lymphoma (EORTC 20884).

    • Berthe M P Aleman, Théodore Girinsky, Richard W M van der Maazen, Simon Strijk, Paul Meijnders, Roberto Bortolus, Manouk J J Olofsen-van Acht, Marnix L M Lybeert, Yolande Lievens, Houchingue Eghbali, Evert M Noordijk, Radka Tomsic, Jacobus H Meerwaldt, Philip M P Poortmans, Wilma G J M Smit, Antonella Pinna, Michel Henry-Amar, John M M Raemaekers, European Organization for Research, and Treatment of Cancer (EORTC) Lymphoma Group.
    • Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands. b.aleman@nki.nl
    • Int. J. Radiat. Oncol. Biol. Phys. 2005 Nov 15; 63 (4): 1184-90.

    PurposeTo evaluate the impact of the quality of involved-field radiotherapy (IFRT) on clinical outcome in patients with advanced Hodgkin's lymphoma (HL) in complete remission (CR) after six to eight cycles of mechlorethamine, vincristine, procarbazine, prednisone-doxorubicin, bleomycin, and vinblastine (MOPP-ABV) chemotherapy.Methods And MaterialsA retrospective review of clinical and radiologic data, radiation charts, simulator films, and megavoltage (MV) photographs was performed. IFRT consisted of 24 Gy to all initially involved nodal areas and 16-24 Gy to all initially involved extranodal sites. Major violations were defined as no or only partial irradiation of an originally involved area, or a total dose <90% of the prescribed dose.ResultsOf the 739 patients who were enrolled in the trial between 1989 and 2000, 57% achieved a CR; 152 of 172 patients randomized to IFRT actually received radiotherapy; and in 135 patients, quality control was performed. The overall major violation rate was 47%, predominantly concerning target volumes. The total dose was correct in 81% of the patients. After a median follow-up of 6.5 years, there was no difference in cumulative failure rate between patients with or without major violations. There was no relationship between incidence or site of relapse and major protocol violations.ConclusionIn advanced-stage HL patients in complete remission after six to eight cycles of MOPP-ABV, the outcome was not influenced by violation of the radiotherapy protocol.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…