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Curr Pain Headache Rep · Jul 2021
ReviewHIV Neuropathy-a Review of Mechanisms, Diagnosis, and Treatment of Pain.
- Kaitlyn E Egan, Gregory M Caldwell, and Maxim S Eckmann.
- Department of Physical Medicine & Rehabilitation, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas, USA. egank@uthscsa.edu.
- Curr Pain Headache Rep. 2021 Jul 8; 25 (8): 55.
Purpose Of ReviewThis article is a systematic review of data from 2018 to 2020 regarding information from publications on epidemiologic, diagnostic, and therapeutic advancements in human immunodeficiency virus-associated peripheral neuropathy.Recent FindingsThe epidemiology/pathology of HIV neuropathy is discussed. Diagnostics includes skin wrinkling-eutectic mixture of local anesthetic test and neurologic examinations. Therapeutic interventions include pharmacologic and nonpharmacologic management as well as self-management strategies. Peripheral neuropathy continues to affect the lives of persons living with HIV. First-line treatment with pregabalin or gabapentin for HIV neuropathic pain has limited data on adequate response. Exercise and self-management strategies may provide benefit in pain reduction. Continuing research on risk factors and biomarkers for HIV-related peripheral neuropathy will be critical for future diagnostic and therapeutic agents.
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