• Seminars in oncology · Apr 2017

    Review

    Angiogenesis inhibition in the second-line treatment of metastatic colorectal cancer: A systematic review and pooled analysis.

    • Ralph Chebib, Loic Verlingue, Nathalie Cozic, Matthieu Faron, Pascal Burtin, Valérie Boige, Antoine Hollebecque, and David Malka.
    • Département de Médecine Oncologique, Gustave Roussy, Université Paris-Saclay, Paris, France.
    • Semin. Oncol. 2017 Apr 1; 44 (2): 114-128.

    AbstractThe last two decades have seen intensive efforts devoted to the development of compounds that target angiogenesis for the treatment of metastatic colorectal cancer (mCRC). In this review, we describe supporting evidence and ongoing development of angiogenesis inhibitors in the second-line treatment of mCRC, and summarize relevant randomized trials to help therapeutic decision-making in daily practice.Copyright © 2017 Elsevier Inc. All rights reserved.

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