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Randomized Controlled Trial Comparative Study Clinical Trial
Maprotiline versus imipramine and placebo in neurotic depression.
- C D van der Velde.
- J Clin Psychiatry. 1981 Apr 1; 42 (4): 138-41.
AbstractThe antidepressant effect of maprotiline, a tetracyclic compound, was compared with that of imipramine in a four-week, double-blind, placebo controlled study with neurotic depressives. On all factors of the Hamilton Depression Rating Scale and on most items of the Zung Self-Rating Scales for Depression and Anxiety, maprotiline appeared slightly more effective than imipramine and showed a faster onset of action. In addition, it appeared to cause fewer anticholinergic side effects.
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