• C Wenus, R Goll, E B Loken, A S Biong, D S Halvorsen, and J Florholmen.
• Department of Clinical Nutrition, University Hospital of North Norway, Tromsoe, Norway. catrin@wenus.net
• Eur J Clin Nutr. 2008 Feb 1; 62 (2): 299-301.

ObjectiveTo study the preventive effect of a milk drink fermented with multistrain probiotics on antibiotic associated diarrhoea (AAD).DesignDouble-blind placebo controlled study.SettingUniversity Hospital of North Norway.Subjects And MethodsOf 853 patients treated with antibiotics, 87 met the inclusion criteria, and were randomized to ingestion of a fermented milk drink containing LGG, La-5 and Bb-12 (n=46) or placebo with heat-killed bacteria (n=41), during a period of 14 days. A diary was recorded, and stool samples were collected for microbiological analyses.ResultsSixty-three patients completed the study according to the protocol; two patients (5.9%) in the treatment group and eight (27.6%) in the placebo group developed AAD (P=0.035). The relative risk of developing AAD was 0.21 (95% confidence interval: 0.05-0.93) when given probiotic milk drink.ConclusionA fermented multistrain probiotic milk drink may prevent four of five cases of AAD in adult hospitalized patients.SponsorshipTINE BA, Oslo, Norway.

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