• Veronica Siton Alcantara, Geok Hoon Lim, Swee Ho Lim, Rehena Sultana, and Jung Ah Lee.
• Breast Department, KK Women's and Children's Hospital, Singapore, Republic of Singapore.
• J Surg Oncol. 2017 Apr 1; 115 (5): 523-537.

Background And ObjectivesTriple negative breast cancer (TNBC) carries a worse prognosis compared to the other subtypes. There have been conflicting studies that race may impact the prognosis of TNBC patients. We aim to determine the incidence and prognosis of TNBC among the different ethnic races in Singapore, and to determine its associated risk factors for prognosis.MethodsPatients diagnosed with invasive breast cancer (BC) from 2005 to 2013 at our tertiary institution were included and divided according to race and subtypes. Demographic and clinical information of non-metastatic TNBC patients were analyzed. Log-rank test, univariate and multivariate Cox proportional hazard regression models were used to find associated risk factors related with overall survival (OS) and disease-free survival (DFS).ResultsAmong 1227 BC patients, 129 (10.5%) had TNBC. TNBC patients had the worst OS (P: 0.0005) and DFS (P: 0.0016) among the subtypes. However, variations in race did not have any difference in OS or DFS among TNBC patients. Axillary lymph node involvement, invasive lobular histology, larger tumor size, and the presence of lymphovascular invasion (LVI) were factors associated with both poor DFS and OS among TNBC patients.ConclusionsRacial variation did not have any impact on the prognosis of the TNBC.© 2017 Wiley Periodicals, Inc.

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