• The EMBO journal · Mar 2021

    Halting SARS-CoV-2: lung organoids step up to the plate.

    • Sandra L Leibel and Xin Sun.
    • Department of Pediatrics, University of California at San Diego, La Jolla, CA, USA.
    • EMBO J. 2021 Mar 1; 40 (5): e107651.

    AbstractDefining the pulmonary cell types infected by SARS-CoV-2 and finding ways to prevent subsequent tissue damage are key goals for controlling COVID-19. Recent work establishing a human lung organoid-derived air-liquid interface model permissive to SARS-CoV-2 infection identifies alveolar type II cells as the primary cell type infected, reports an infection-induced interferon response and demonstrates the effectiveness of interferon lambda 1 treatment in dampening lung infection.© 2021 The Authors.

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