• DilektasliAsli GorekAGRehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Building CDCRC, Torrance, CA 90502, USA; Faculty of Medicine, Department of Pulmonary Medicine, Ul, Janos Porszasz, William W Stringer, and Richard Casaburi.
• Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Building CDCRC, Torrance, CA 90502, USA; Faculty of Medicine, Department of Pulmonary Medicine, Uludağ University, Turkey.
• Clin. Chest Med. 2019 Jun 1; 40 (2): 385-395.

AbstractSupplemental long-term oxygen therapy (LTOT) is a well-established therapy that improves mortality in patients with chronic obstructive pulmonary disease (COPD) with resting hypoxemia. In the large number of patients with COPD who do not have severe resting hypoxemia but who desaturate with exercise, the clinical benefits that can be obtained by supplemental O2 therapy during exercise is an area of interest and active research. A summary of current evidence for benefits of supplemental O2 therapy and a review of physiologic mechanisms underlying published observations are reviewed in this article.Copyright © 2019 Elsevier Inc. All rights reserved.

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