• Adnan Majid, Fayez Kheir, Melibea Sierra-Ruiz, Christian Ghattas, Mihir Parikh, Colleen Channick, Colleen Keyes, Alex Chee, Sebastian Fernandez-Bussy, Sidhu Gangadharan, and Erik Folch.
• Department of Interventional Pulmonology, Beth Israel Deaconess Medical Center, Boston, Massachusetts. Electronic address: amajid@bidmc.harvard.edu.
• Ann. Thorac. Surg. 2019 Feb 1; 107 (2): 407-411.

BackgroundIntrabronchial valves (IBVs) are a treatment alternative for persistent air leak (PAL). However, there is a paucity of evidence regarding whether the absence of collateral ventilation (CV) can predict successful treatment of PAL with IBV placement. We assessed whether absence of CV measured by fissure integrity could predict successful resolution of PAL with IBV placement.MethodsA multicenter, retrospective study was performed. Patients who underwent IBV placement for PAL were identified. Chest computed tomography analysis via VIDA Diagnostics was used to assess CV. CV was present if the treated lobe was adjacent to a fissure that was <90% complete.ResultsA total of 81 valves were placed in 26 patients (median, 3 per patient). A total of 16 patients without CV underwent IBV placement: 14 patients had complete resolution of PAL with a median time from IBV placement to air leak resolution of 4.5 days and 2 patients required subsequent procedures to manage the PAL. In a subset of patients without CV who underwent complete lobar occlusion with IBV (n = 8), median time to PAL resolution was 3 days, whereas in patients without CV who underwent incomplete lobar occlusion with IBV (n = 6), median time PAL resolution was 6.5 days (p = 0.045). All 10 patients with CV underwent IBV placement and complete lobar occlusion: 4 patients had complete PAL resolution with a median time from IBV placement to PAL resolution of 17.5 days and 6 patients required subsequent procedures to manage their PAL.ConclusionsPAL treatment with IBV is more successful in patients without CV, especially when complete lobar occlusion with IBV is achieved.Copyright © 2019 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

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