• Matthew J Hankerson, Brian Raffetto, William K Mallon, and Jan M Shoenberger.
• Department of Emergency Medicine, Keck School of Medicine of the University of Southern California , Los Angeles, California.
• J Palliat Med. 2015 Dec 1; 18 (12): 1060-2.

BackgroundMany patients with cancer involving the respiratory system suffer from the frequent recurrence of significant, submassive hemoptysis, which may result in invasive procedures, hospital stays, and a reduction in quality of life. Currently, there are no widely accepted noninvasive therapeutic options. Few case studies have looked at the benefit of tranexamic acid (TXA) as a noninvasive therapy in the treatment of hemoptysis.MethodsA patient with an invasive airway malignancy presented to the emergency department with substantial hemoptysis. A nebulized TXA solution was used as a noninvasive therapy to control the hemorrhage.ResultsThe patient's hemoptysis resolved fifteen minutes after the nebulized TXA therapy was initiated. There were no known adverse events.ConclusionNebulized TXA seems to be a safe, effective, and noninvasive method for controlling, or at least temporizing, hemoptysis in select patients. Nebulized TXA may be useful as a palliative therapy for chronic hemoptysis and as a tool in the acute stabilization of hemoptysis.

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