• Dominique Hansen, Paul Dendale, Anita Raskin, Annick Schoonis, Jan Berger, Irmien Vlassak, and Romain Meeusen.
• Jessa Hospital, Rehabilitation and Health Centre, Heart Centre Hasselt, Hasselt and Vrije Universiteit Brussel, Department of Human Physiology and Sportsmedicine, Brussels, Belgium. rmeeusen@vub.ac.be
• Clin Rehabil. 2010 Apr 1; 24 (4): 319-27.

ObjectiveTo assess whether exercise volume during phase II rehabilitation affects long-term clinical benefits in patients with coronary artery disease.DesignProspective randomized clinical trial with long-term follow-up.SettingHospital outpatient clinic.SubjectsCoronary artery disease patients (age 65 +/- 9 years, 82% males) attending a phase II rehabilitation programme were randomized into two groups of exercise volumes: 40- versus 60-minute training sessions. Patients exercised for three days per week for seven weeks, at 65% of baseline oxygen uptake capacity. Next, they were followed up for 18 months. Out of 165 patients with coronary artery disease who completed the exercise intervention, 119 attended the 18-month follow-up assessment.Main MeasurementsBody anthropometrics, resting haemodynamics, blood lipid profile, glycaemia, and C-reactive protein level, smoking behaviour, habitual physical activity, cardiovascular disease incidence and mortality.ResultsIn total population, a significant worsening of various cardiovascular disease risk factors was found at 18 months follow-up (P<0.05), and few patients (27% of total group) adhered to the recommended minimal physical activity level. No difference in change of body anthropometrics, resting haemodynamics, blood lipid profile, glycaemia, and C-reactive protein level, and smoking behaviour was seen between different exercise volumes (P>0.05). In addition, total cardiovascular disease incidence (13% versus 22% in 40- versus 60-minute group, respectively) and habitual physical activity were not different between groups (P>0.05).ConclusionIn patients with coronary artery disease following cardiac rehabilitation, the cardiovascular disease risk profile worsened significantly during long-term follow-up. A smaller exercise volume during phase II rehabilitation generated equal long-term clinical benefits compared to a greater exercise volume.

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