-
- W M King and N R Kreisman.
- Brain Res. 1981 Mar 23; 209 (1): 221-6.
AbstractThe anticonvulsant, trimethadione (TMO), was tested for effects on cholinergic responses to iontophoretic application of ACh on identified neurons in Aplysia. TMO (1--10 mM) depressed the amplitudes of depolarizing responses mediated by Na+ and hyperpolarizing responses mediated by Cl- but did not affect hyperpolarizing responses mediated by K+. Such a combination of effects on cholinergic responses distinguishes the action of this anti-absence drug from agents effective against tonic-clonic seizures and from convulsive drugs.
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