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Int. J. Antimicrob. Agents · Jan 2006
Integron-associated imipenem resistance in Acinetobacter baumannii isolated from a regional hospital in Taiwan.
- S Y Liu, J Y Lin, C Chu, L H Su, T Y Lin, and C H Chiu.
- Department of Molecular Biotechnology, Da-Yeh University, Changhua, Taiwan.
- Int. J. Antimicrob. Agents. 2006 Jan 1; 27 (1): 81-4.
AbstractWe investigated the genetic properties of imipenem-resistant Acinetobacter baumannii collected from a regional hospital in Taiwan. Pulsed-field gel electrophoresis demonstrated that the isolates were genetically diverse. Polymerase chain reaction, DNA sequencing, and DNA-DNA hybridisation showed that the bla(IMP-1) gene resided as a cassette in a plasmid-borne class 1 integron in two isolates. The majority of the resistant isolates were plasmid-less and carried no bla(IMP), bla(VIM) or bla(CFI) genes, indicating that other uncharacterised metallo-beta-lactamases or mechanisms other than enzyme production are involved in carbapenem resistance in this group of A. baumannii. We conclude that multidrug resistance of A. baumannii was a combined effect of lateral gene transfer and clonal spread of multiple resistant clones. Strict measures should be implemented to control the further spread of resistance.
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