• Jan Claassen, Yama Akbari, Sheila Alexander, Mary Kay Bader, Kathleen Bell, Thomas P Bleck, Melanie Boly, Jeremy Brown, Sherry H-Y Chou, Michael N Diringer, Brian L Edlow, Brandon Foreman, Joseph T Giacino, Olivia Gosseries, Theresa Green, David M Greer, Daniel F Hanley, Jed A Hartings, Raimund Helbok, J Claude Hemphill, H E Hinson, Karen Hirsch, Theresa Human, Michael L James, Nerissa Ko, Daniel Kondziella, Sarah Livesay, Lori K Madden, Shraddha Mainali, Stephan A Mayer, Victoria McCredie, Molly M McNett, Geert Meyfroidt, Martin M Monti, Susanne Muehlschlegel, Santosh Murthy, Paul Nyquist, DaiWai M Olson, J Javier Provencio, Eric Rosenthal, Sampaio SilvaGiseleGDepartment of Neurology, Albert Einstein Israelite Hospital and Universidade Federal de São Paulo, São Paulo, Brazil., Simone Sarasso, Nicholas D Schiff, Tarek Sharshar, Lori Shutter, Robert D Stevens, Paul Vespa, Walter Videtta, Amy Wagner, Wendy Ziai, John Whyte, Elizabeth Zink, Jose I Suarez, and Curing Coma Campaign.
• Department of Neurology, Columbia University and New York-Presbyterian Hospital, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York City, NY, 10032, USA. jc1439@columbia.edu.
• Neurocrit Care. 2021 Jul 1; 35 (Suppl 1): 4-23.

AbstractComa and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to organize a symposium bringing together experts from all over the world to develop research targets for DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof-of-concept clinical trials, (4) neuroprognostication, (5) long-term recovery, and (6) large datasets. This proceedings paper presents actionable research targets based on the presentations and discussions that occurred at the conference. We summarize the background, main research gaps, overall goals, the panel discussion of the approach, limitations and challenges, and deliverables that were identified.

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