• A Pession, R Rondelli, P Paolucci, G Pastore, G Dini, F Bonetti, E Madon, F Mandelli, L Zanesco, C Uderzo, A Prete, M Rabusin, A Ugazio, P Di Bartolomeo, C Favre, L Bojd-Faulkner, V Poggi, R Luksch, A Donfrancesco, F Argiolu, G La Nasa, A Amici, and F Locatelli.
• Department of Pediatrics, University of Bologna, Ospedle Sant'Orsola, Bologna, Italy. pession@med.unibo.it.
• Haematologica. 2000 Jun 1; 85 (6): 638-46.

Background And ObjectiveTransplantation of hematopoietic stem cells from different sources is being increasingly used to treat a variety of diseases in children. Transplant procedures and indications have changed considerably during recent years. Monitoring of information about these changes is useful for interpretation of nationwide collected data.Design And MethodsSince 1985, Centers belonging to the AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica), performing hematopoietic stem cell transplants (HSCT) in children, and members of the AIEOP-Bone Marrow Transplant (BMT) Group annually report data on their transplant activity to the AIEOP-BMT Registry employing specially prepared patient-oriented forms.ResultsFrom January 1985 to December 1998, a total of 2,474 bone marrow (BM), peripheral blood (PB) or umbilical cord blood (CB) transplants were reported: 1,296 (52%) were allogeneic (Allo) and 1,178 (48%) autologous (Auto) transplants. These transplants were performed in 19 Italian Centers on 2,249 patients aged less than 17 years. Among Allo-transplants, 1,198 (92%) were performed using BM progenitor cells, whereas 49 (4%) CB, 42 (3%) were PB, 4 BM plus PB, and 3 BM plus CB allografts; they were performed using HLA-identical sibling donors in 867 cases (67%) and alternative donors (i.e. partially-matched relatives or unrelated donors) in the remaining 429 (33%) cases. Allogeneic transplants were performed on 786 (67%) patients with malignancy and on 395 (33%) patients with non-malignant disorders. In the last 6 years, the number of Allo-transplants per year exceeded that of Auto-transplants. Of the Auto-transplants, 775 (66%) were performed using BM, and 403 (34%) using PB alone or combined with BM hematopoietic stem cells. Indications for Auto-BMT were myelo-lymphoproliferative disorders in 524 (49%) cases, solid tumor in 533 (50%) cases and non-malignant disease in 11 (1%) cases. In the last 5 years, the use of PB for autografts has increased from 7% to 70%.Interpretation And ConclusionsThese data reflect the development and present status of HSCT in Italy and provide a basis for patient counseling and health care planning.

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